Mouth and Facial Changes Linked to Ozempic Use
Changes in the mouth are now being added to a growing list of physical side effects reported by Ozempic users. These symptoms are part of a broader phenomenon often referred to as “Ozempic face,” where rapid weight loss leads to sunken cheeks, hollowed eyes, and a noticeably gaunt appearance. Some users also report dramatic changes in other areas of the body — including overly wrinkled feet and loss of fat in the buttocks — leaving them feeling uncomfortable when sitting. Together, these effects highlight how the medication alters the body far beyond simple weight reduction.
Millions Could Experience These Effects
Roughly one in eight Americans has tried injectable weight-loss drugs, though the real number may be even higher. Many users don’t disclose their use due to stigma, while others rely on compounded versions that aren’t officially tracked. Originally developed to treat diabetes, these medications are now widely used for weight loss — especially among celebrities and public figures. As their popularity has surged, so have reports of cosmetic side effects, which are increasingly visible on social media and red carpets alike. With millions now using these drugs, facial changes may soon become a common side effect.
Fixing Ozempic Mouth Comes at a Cost
According to Dr. Green, more patients than ever are seeking dermal fillers to correct changes around the mouth caused by rapid fat loss. These injectable gels restore volume beneath the skin, smoothing wrinkles and helping the face regain fullness. While effective, the solution is expensive. Each syringe can cost anywhere from $700 to $2,000, depending on the provider and location. Most patients require multiple syringes per session to see noticeable improvement, making the overall price steep.
A High-Tech Alternative Gains Attention
Another option growing in popularity is Thermage, a non-invasive procedure that uses radiofrequency energy to heat the deeper layers of skin. This process stimulates collagen production, helping tighten and firm sagging areas over time. While results aren’t immediate — typically taking four to six months to appear — improvements can last up to 18 months. The downside is cost: a single 30-minute treatment can range from $1,500 to $3,500, placing it out of reach for many.
How to Reduce the Risk of Facial Changes
Doctors say some of these effects may be preventable. Dr. Green recommends discussing slower weight-loss plans with healthcare providers, allowing the skin time to adjust naturally. Gradual fat loss reduces the chances of sagging and hollowing. Dr. Ramer Bass of Mount Sinai also advises eating protein-rich, fiber-filled meals to support skin elasticity and hydration. She encourages patients to consult a dermatologist early — before visible damage occurs — rather than trying to reverse changes later.
Beauty Industry Cashes In on the Trend
The cosmetic industry has seen a dramatic rise in demand. Dermal filler procedures in the U.S. have nearly tripled over the past decade, increasing from 1.8 million in 2010 to 5.3 million in 2023. This surge closely mirrors the growing use of weight-loss injections. As more people turn to prescription solutions for slimming down, aesthetic clinics are expanding services to address the unintended physical consequences.
The Cost Most People Don’t Anticipate
The financial impact goes far beyond monthly medication costs. Maintaining facial volume after weight loss can require ongoing cosmetic treatments that add up to thousands of dollars each year. Many users need repeated sessions or a combination of procedures to maintain results. For those considering Ozempic or similar drugs, experts warn that the real investment isn’t just physical — it’s financial too. Understanding these long-term costs ahead of time may help patients make more informed decisions before starting treatment.
